Living with treatment-resistant hypertension can be disheartening, but it doesn’t have to be. We want to help.
Join us in the search for an effective hypertension therapy.
What is the purpose of the Brightn study?
The goal of the Brightn study is to see if the investigational study drug (CIN-107) can help lower blood pressure in people who are no longer responding to their current hypertension medications.
Brightn is a Phase 2 study. If you don’t know whats is Phase 2 study, you can go to this link for more info.
How could the study drug help your hypertension?
The study drug is designed to target aldosterone, a hormone that helps regulate blood pressure in the body. The aldosterone pathway, which produces aldosterone, is sometimes targeted by hypertension medications to help lower blood pressure. However, aldosterone may increase again even if you are taking medications, potentially increasing blood pressure. When medications no longer help control your blood pressure, this is called treatment-resistant hypertension.
The study drug is designed to work with your current medications to reduce aldosterone and to help manage your hypertension.
What can you expect during the study?
If you choose to participate in the study, you can expect the following:
- Screening period (up to 8 weeks). Visit the study clinic to find out if you qualify. You may need to adjust your hypertension medications during this period.
- Run-in period (2 weeks). Take your hypertension medications and the study drug* daily for 2 weeks. During this period, only the study doctor will know what study drug you are taking.
- Treatment period (13 weeks). If you still qualify after the Run-in period, you will take your hypertension medications and the study drug* daily for 13 weeks and attend study clinic visits. During this period, neither you nor the study doctor will know what study drug you are taking.
- Follow-up phone call (1 week). Receive a follow-up phone call from the study staff after your last study clinic visit.
* You will receive either the investigational study drug or a placebo (no active drug ingredients).
Can you participate in the Brightn study?
If you meet the following requirements, you may qualify for the Brightn study:
- You are an adult (at least 18 years old) with hypertension.
- You are taking hypertension medications on a regular basis. Note: You may have to adjust the medications you are taking to meet study requirements.
- You have a blood pressure of at least 140/90 but less than 180/110.
- You do not work night shifts.